Synphot simulates photometric data and spectra, observed or otherwise. It can incorporate the user's filters, spectra, and data, and use of a pre-defined standard star (Vega), bandpass, or extinction law. synphot can also construct complicated composite spectra using different models, simulate observations, and compute photometric properties such as count rate, effective wavelength, and effective stimulus. It can manipulate a spectrum by, for example, applying redshift, or normalize it to a given flux value in a given bandpass. Synphot can also sample a spectrum at given wavelengths, plot a quick-view of a spectrum, and perform repetitive operations such as simulating the observations of multiple type of sources through multiple bandpasses. Synphot understands Astropy (ascl:1304.002) models and units and is an Astropy affiliated package. Support for HST and JWST is available through the extension stsynphot (ascl:2010.003).