ProFuse produces physical models of galaxies and their components by combining the functionalities of the source extraction code PROFOUND (ascl:1804.006), the Bayesian galaxy fitting tool ProFit (ascl:1612.004), and the spectral generation package ProSpect (ascl:2002.007). ProFuse uses a self-consistent model for the star formation and metallicity history of the bulge and disk separately to generate images. The package then defines the model likelihood and optimizes the physical galaxy reconstruction using target images across a range of wavelengths.