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PLUTO is a modular Godunov-type code intended mainly for astrophysical applications and high Mach number flows in multiple spatial dimensions. The code embeds different hydrodynamic modules and multiple algorithms to solve the equations describing Newtonian, relativistic, MHD, or relativistic MHD fluids in Cartesian or curvilinear coordinates. PLUTO is entirely written in the C programming language and can run on either single processor machines or large parallel clusters through the MPI library. A simple user-interface based on the Python scripting language is available to setup a physical problem in a quick and self-explanatory way. Computations may be carried on either static or adaptive (structured) grids, the latter functionality being provided through the Chombo adaptive mesh refinement library.