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PyVO provides access to remote data and services of the Virtual observatory (VO) using Python. It takes advantage VO standards to interface to tens of thousands of catalogs, data archives, information services, and analysis tools. PyVO is built on top of Astropy (and numpy). The VO protocols support by pyVO include the Table Access Protocol TAP, the Simple Image and Spectra Access Protocols (SIAP, SSAP), Simple Cone Search (SCS), the VO services interface VOSI, and Datalink.