Pylians facilitates the analysis of numerical simulations (both N-body and hydro). This set of libraries, written in python, cython and C, compute power spectra, bispectra, and correlation functions, identifies voids, and populates halos with galaxies using an HOD. Pylians can also apply HI+H2 corrections to the output of hydrodynamic simulations, makes 21cm maps, computes DLAs column density distribution functions, and plots density fields. A Python 3 version of this code, Pylians3 (ascl:2403.012) is available.