RealSim-IFS generates survey-realistic integral-field spectroscopy (IFS) observations of galaxies from numerical simulations of galaxy formation. The tool is designed primarily to emulate current and experimental observing strategies for IFS galaxy surveys in astronomy, and can reproduce both the flux and variance propagation of real galaxy spectra to cubes. RealSim-IFS has built-in functions supporting SAMI and MaNGA IFU footprints, but supports any fiber-based IFU design, in general.