Nextflow enables scalable and reproducible scientific workflows using software containers. It allows the adaptation of pipelines written in the most common scripting languages. Its fluent DSL simplifies the implementation and the deployment of complex parallel and reactive workflows on clouds and clusters. Nextflow supports deploying workflows on a variety of execution platforms including local, HPC schedulers, AWS Batch, Google Cloud Life Sciences, and Kubernetes. Additionally, it provides support for workflow dependencies through built-in support for, for example, Conda, Spack, Docker, Podman, Singularity, and Modules.