Hierarchical Semi-Sparse Cube (HiSS-Cube) framework provides highly parallel processing of combined multi-modal multi-dimensional big data. The package builds a database on top of the HDF5 framework which supports parallel queries. A database index on top of HDF5 can be easily constructed in parallel, and the code supports efficient multi-modal big data combinations. The performance of HiSS-Cube is bounded by the I/O bandwidth and I/O operations per second of the underlying parallel file system; it scales linearly with the number of I/O nodes and can be extended to any kind of multidimensional data combination and information retrieval.