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The PLUTO CLOUDY Interface (TPCI) combines the PLUTO (ascl:1010.045) and CLOUDY (ascl.net:9910.001) simulation codes to simulate hydrodynamic evolution under irradiation from a source. The code solves the photoionization and chemical network of the 30 lightest elements. By combining an equilibrium photoionization solver with a general MHD code, TPCI provides an advanced simulation tool applicable to a variety of astrophysical problems.