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PynPoint processes and analyzes high-contrast imaging data of exoplanets and circumstellar disks. The generic, end-to-end pipeline's modular architecture separates the core functionalities and the pipeline modules. These modules have specific tasks such as background subtraction, frame selection, centering, PSF subtraction with principal component analysis, estimation of detection limits, and photometric and astrometric analysis. All modules store their results in a central database. Management of the available hardware by the backend of the pipeline is in particular an advantage for data sets containing thousands of images, as is common in the mid-infrared wavelength regime. This version of PynPoint is a significant rewrite of the earlier PynPoint package (ascl:1501.001).