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EXOSIMS generates and analyzes end-to-end simulations of space-based exoplanet imaging missions. The software is built up of interconnecting modules describing different aspects of the mission, including the observatory, optical system, and scheduler (encoding mission rules) as well as the physical universe, including the assumed distribution of exoplanets and their physical and orbital properties. Each module has a prototype implementation that is inherited by specific implementations for different missions concepts, allowing for the simulation of widely variable missions.