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ODTBX (Orbit Determination Toolbox) provides orbit determination analysis, advanced mission simulation, and analysis for concept exploration, proposal, early design phase, and/or rapid design center environments. The core ODTBX functionality is realized through a set of estimation commands that incorporate Monte Carlo data simulation, linear covariance analysis, and measurement processing at a generic level; its functions and utilities are combined in a flexible architecture to allow modular development of navigation algorithms and simulations. ODTBX is written in Matlab and Java.