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HHTpywrapper is a python interface to call the Hilbert–Huang Transform (HHT) MATLAB package. HHT is a time-frequency analysis method to adaptively decompose a signal, that could be generated by non-stationary and/or nonlinear processes, into basis components at different timescales, and then Hilbert transform these components into instantaneous phases, frequencies and amplitudes as functions of time. HHT has been successfully applied to analyzing X-ray quasi-periodic oscillations (QPOs) from the active galactic nucleus RE J1034+396 (Hu et al. 2014) and two black hole X-ray binaries, XTE J1550–564 (Su et al. 2015) and GX 339-4 (Su et al. 2017). HHTpywrapper provides examples of reproducing HHT analysis results in Su et al. (2015) and Su et al. (2017). This project is originated from the Astro Hack Week 2015.