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The Lomb-Scargle periodogram is a common tool in the frequency analysis of unequally spaced data equivalent to least-squares fitting of sine waves. GLS is a solution for the generalization to a full sine wave fit, including an offset and weights (χ2 fitting). Compared to the Lomb-Scargle periodogram, GLS is superior as it provides more accurate frequencies, is less susceptible to aliasing, and gives a much better determination of the spectral intensity.
The PyA (PyAstronomy) suite of astronomy-related packages includes a convenient fitting package that provides support for minimization and MCMC sampling, a set of astrophysical models (e.g., transit light-curve modeling), and algorithms for timing analysis such as the Lomb-Scargle and the Generalized Lomb-Scargle periodograms.