nuSpaceSim simulates upward-going extensive air showers caused by neutrino interactions with the atmosphere. It is an end-to-end, neutrino flux to space-based signal detection, modeling tool for the design of sub-orbital and space-based neutrino detection experiments. This comprehensive suite of modeling packages accepts an experimental design input and then models the experiment's sensitivity to both the diffuse, cosmogenic neutrino flux as well as astrophysical neutrino transient events, such as that postulated from binary neutron star (BNS) mergers. nuSpaceSim calculates the tau neutrino acceptance for the Optical Cherenkov technique; tau propagation is interpolated using included data tables from nupyprop (ascl:2306.044). The simulation is parameterized by an input XML configuration file, with settings for detector characteristics and global parameters; nuSpaceSim also provides a python API for programmatic access.