pySPEDAS (Python-based Space Physics Environment Data Analysis Software) supports multi-mission, multi-instrument retrieval, analysis, and visualization of heliophysics time series data. A Python implementation of SPEDAS (ascl:2405.001), it supports most of the capabilities of SPEDAS; it can load heliophysics data sets from more than 30 space-based and ground-based missions, coordinate transforms, interpolation routines, and unit conversions, and provide interactive access to numerous data sets. pySPEDAS also creates multi-mission, multi-instrument figures, includes field and wave analysis tools, and performs magnetic field modeling, among other functions.