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DarkFlux analyzes indirect-detection signatures for next-generation models of dark matter (DM) with multiple annihilation channels. Input is user-generated models with 2 → 2 tree-level dark matter annihilation to pairs of Standard Model (SM) particles. The code analyzes DM annihilation to γ rays using three modules; one computes the fractional annihilation rate, the second computes the total flux at Earth due to DM annihilation, and the third compares the total flux to observational data and computes the upper limit at 95% confidence level (CL) on the total thermally averaged DM annihilation cross section.