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PyFOSC is a pipeline toolbox for long-slit spectroscopy data reduction written in Python. It can be used for FOSC (Faint Object Spectrograph and Camera) data from Xinglong/Lijiang 2-meter telescopes in China. This pipeline privodes a neat way for data pre-processing, including updating missing header fileds for BFOSC data, reducing fits file extension for YFOSC data, etc. And it makes the data reduction procedure efficient by using previously identified lamp spectra as re-identification references during wavelength calibration, and applying multiprocessing in some modules. PyFOSC also enables customization for any other long-slit spectroscopy data.