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POSYDON (POpulation SYnthesis with Detailed binary-evolution simulatiONs) incorporates full stellar structure and evolution modeling for single and binary-star population synthesis. The code is modular and allows the user to specify initial population properties and adopt choices that determine how stellar evolution proceeds. Populations are simulated with the use of MESA (ascl:1010.083) evolutionary tracks for single, non-interacting, and interacting binaries organized in grids. Machine-learning methods are incorporated and applied on the grids for classification and various interpolation calculations, and the development of irregular grids guided by active learning, for computational efficiency.