Pyxel hosts and pipelines models (analytical, numerical, statistical) simulating different types of detector effects on images produced by Charge-Coupled Devices (CCD), Monolithic, and Hybrid CMOS imaging sensors. Users can provide one or more input images to Pyxel, set the detector and model parameters, and select which effects to simulate, such as cosmic rays, detector Point Spread Function (PSF), electronic noises, Charge Transfer Inefficiency (CTI), persistence, dark current, and charge diffusion, among others. The output is one or more images including the simulated detector effects combined. The Pyxel framework, written in Python, provides basic image analysis tools, an input image generator, and a parametric mode to perform parametric and sensitivity analysis. It also offers a model calibration mode to find optimal values of its parameters based on a target dataset the model should reproduce.