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SPISEA (Stellar Population Interface for Stellar Evolution and Atmospheres) generates single-age, single-metallicity populations (i.e., star clusters). The software (formerly called PyPopStar) provides control over different parameters, including cluster characteristics (age, metallicity, mass, distance); total extinction, differential extinction, and extinction law; stellar evolution and atmosphere models; stellar multiplicity and Initial Mass Function; and photometric filters. SPISEA can be used to create a cluster isochrone in many filters using different stellar models, generate a star cluster at any age with an unusual IMF and unresolved multiplicity, and make a spectrum of a star cluster in integrated light.