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ORIGIN performs blind detection of faint emitters in MUSE datacubes. The algorithm is tuned to detect faint spatial-spectral emission signatures while allowing for a stable false detection rate over the data cube, and providing in the same time an automated and reliable estimation of the purity. ORIGIN implements a nuisance removal part based on a continuum subtraction combining a Discrete Cosine Transform and an iterative Principal Component Analysis and a detection part based on the local maxima of Generalized Likelihood Ratio test statistics obtained for a set of spatial-spectral profiles of emission line emitters. In addition, it performs a purity estimation in which the proportion of true emission lines is estimated from the data itself: the distribution of the local maxima in the noise only configuration is estimated from that of the local minima.