JetSeT reproduces radiative and accelerative processes acting in relativistic jets and fits the numerical models to observed data. This C/Python framework re-bins observed data, can define data sets, and binds to astropy tables and quantities. It can use Synchrotron Self-Compton (SSC), external Compton (EC) and EC against the CMB when defining complex numerical radiative scenarios. JetSeT can constrain the model in the pre-fitting stage based on accurate and already published phenomenological trends starting from parameters such as spectral indices, peak fluxes and frequencies, and spectral curvatures. The package fits multiwavelength SEDs using both frequentist approach and Bayesian MCMC sampling, and also provides self-consistent temporal evolution of the plasma under the effect of radiative and accelerative processes for both first order and second order (stochastic acceleration) processes.