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Astropy provides a common framework, core package of code, and affiliated packages for astronomy in Python. Development is actively ongoing, with major packages such as PyFITS, PyWCS, vo, and asciitable already merged in. Astropy is intended to contain much of the core functionality and some common tools needed for performing astronomy and astrophysics with Python.
Astroquery allows users to access online astronomical data from a wide range of sources; it is an Astropy-affiliated package. Each web service has its own sub-package for interfacing with a particular data source.
healpy handles pixelated data on the sphere. It is based on the Hierarchical Equal Area isoLatitude Pixelization (HEALPix) scheme and bundles the HEALPix (ascl:1107.018) C++ library. healpy provides utilities to convert between sky coordinates and pixel indices in HEALPix nested and ring schemes and find pixels within a disk, a polygon or a strip in the sky. It can apply coordinate transformations between Galactic, Ecliptic and Equatorial reference frames, apply custom rotations either to vectors or full maps, and read and write HEALPix maps to disk in FITS format. healpy also includes utilities to upgrade and downgrade the resolution of existing HEALPix maps and transform maps to Spherical Harmonics space and back using multi-threaded C++ routines, among other utilities.